Les littératures scientifiques montrent que :

  • Après la désagrégation, la viabilité dans la micro-greffe s'élève à 75-80%
  • La fraction stromale vasculaire contient un pourcentage élevé de cellules endothéliales et de péricytes qui, à leur tour, jouent un rôle clé dans la régénération tissulaire, favorisant la revascularisation post-traumatique.
  • Rigenera améliore la guérison des lésions osseuses comme suggéré par l'utilisation de micro-greffes obtenues avec du périoste en association avec de l'éponge de collagène.
  • Rigenera est efficace dans le processus de guérison des plaies améliorant la réépithélisation de la plaie et réduisant sa taille ainsi que dans la prise en charge des ulcères, favorisant le développement du tissu de granulation.
  • Rigenera permet d'augmenter la densité des cheveux d'environ 29% à 23 semaines.

Dr Gentile étude alopécie androgénique Rigenera

Pinto H., Galvez R., Casanova J. Dermoscopy is the crucial step for proper outcome prospection when treating androgenetic alopecia with the Regenera Protocol : a score proposal. International Journal of Clinical and Development Anatomy; 2018; doi: 10.11648/j.ijcda.20180401.12

 

Metanomski M. Nouvelle technique thérapeutique pour l'alopécie : la mésogreffe. https://www.afme.org/visage/cheveux/nouvelle-technique-therapeutique-pour-lalopecie-la-mesogreffe/ Février 2018

 

Gentile P., Scioli M.G., Bielli A., Orlandi A., Cervelli V. Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss. Stem Cells Investigation 2017; doi 10.21037/sci.2017.06.04

 

D’Aquino R., De Rosa A., Lanza V., Tirino V., Laino L., Graziano A., Desiderio, Gregorio V., Laino and Gianpaolo Papaccio. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. European Cells and Materials 2009; 18:73-85

 

Aimetti M, Ferrarotti F, Mariani GM, Cricenti L, Romano F., Use of Dental Pulp Stem Cells/Collagen Sponge Biocomplex in the Treatment of Non-contained Intrabony Defects: A Case Series. Clinical Advances in Periodontics, 2013; doi 10.902/cap.2013.130047

 

Giaccone M, Brunetti M, Camandona M, Trovato L. and Graziano A., A New Medical Device, Based on Rigenera Protocol, in the Management of Complex Wounds. J Stem Cells Res, Rev & Rep. 2014;1(3): 3.

 

Rodriguez R, D’Aquino R, Trovato L, Graziano A, Human Tissue Regeneration in Maxillo-facial Area: From Stem Cells to Micrografts. Current Tissue Engineering, 4, 36-40 (2211-5439/15) (2015)

 

Graziano A, Carinci F, Scolaro S, D’Aquino R., Periodontal tissue generation using autologous dental ligament micro-grafts: case report with 6 months follow-up. AOMS. 1(2), 20, (2013).

 

Aimetti M, Ferrarotti F, Cricenti L, Mariani GM, Romano F., Autologous dental pulp stem cells in periodontal regeneration: a case report. Int J Periodontics Restorative Dent. 34 (3), s27-33, doi: 10.11607/prd.1635, (2014)

 

Brunelli G, Motroni A, Graziano A, D’Aquino R et al., Sinus lift tissue engineering using autologous pulp micro-grafts: A case report of bone density evaluation. J Indian Soc Periodontol. 17 (5), 644-7, doi: 10.4103/0972-124X.119284,

(2013)

 

Purpura V, Bondioli E, Graziano A, Trovato L, Melandri D, Ghetti M, Marchesini A, Cusella de Angelis MG, Benedetti L, Ceccarelli G, Riccio M., Tissue characterization after a new disaggregation method for skin micro-grafts generation. J Vis Exp 2016;109:e53579. doi:10.3791/53579.

 

Trovato L, Monti M, Del Fante C, Cervio M, Lampinen M, Ambrosio L, Redi CA, Perotti C, Kankuri E, Ambrosio G, Rodriguez Y Baena R, Pirozzi G, Graziano A., A new medical device Rigeneracons allows to obtain viable micro-grafts from mechanical disaggregation of human tissues. J Cell Physiol 2015;230:2299–303.

 

Trovato L, Failla G, Serantoni S, Palumbo FP (2016), Regenerative Surgery in the Management of the Leg Ulcers. J Cell Sci Ther 7: 238. doi:10.4172/21577013.1000238

 

D’Aquino R, Trovato L, Graziano A, Ceccarelli G, de Angelis GC, et al.(2016), Periosteum-derived micro-grafts for tissue regeneration of human maxillary bone. J TranslSci2: doi: 10.15761/JTS.1000128

 

Monti, M., Graziano, A., Rizzo, S., Perotti, C., Del Fante, C., d’Aquino, R., Redi, C. A. and Rodriguez y Baena, R. (2016), In Vitro and In Vivo Differentiation of Progenitor Stem Cells Obtained After Mechanical Digestion of Human Dental

Pulp. J. Cell. Physiol.. doi:10.1002/jcp.25452

 

Gentile P, Scioli MG, Bielli A, Orlandi A, Cervelli V (2016), A combined use of Chondrocytes Micro Grafts (CMG) Mixed with Platelet Rich Plasma (PRP) in Patients Affected by Pinch Nose Deformity. J Regen Med 5:2.

 

Zanzottera F, Lavezzari E, Trovato L, Icardi A, Graziano A. Adipose Derived Stem Cells and Growth Factors Applied on Hair Transplantation. Follow-Up of Clinical Outcome. JCDSA. 4(4), 268-74, http://dx.doi.org/10.4236/jcdsa. 2014.44036, (2014)

 

Svolacchia F, De Francesco F, Trovato L, Graziano A, Ferraro GA. An innovative regenerative treatment of scars with dermal micrografts. J Cosmet Dermatol 2016. DOI: 10.1111/jocd.12212